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In order for AppGuard to allow Sandboxie to function properly a few settings must be tweaked.

• Open the main AppGuard window and click on “Customize…”
• Switch over to the “Advanced” tab and click on “Add” under the MemoryGuard settings.
• Navigate to your Sandboxie install location (default is C:\Program Files\Sandboxie).
• We will be adding the following 3 Sandboxie executables with “Write” permission:
      1.  sandboxierpcss.exe
      2.  sandboxiedcomlaunch.exe
      3.  sandboxiecrypto.exe
• Now switch over to the “Guarded Apps” tab and click on “Settings…” under Folders.
• Add your main sandbox folder (the default location is at C:\Sandbox) with Read/Write permissions.

That’s all there is to it. Now Sandboxie should have no issues running alongside AppGuard.